Anthelmintic efficacies of a tablet formula of ivermectin-praziquantel on horses experimentally infected with three Strongylus species
Identifieur interne : 005D82 ( Main/Exploration ); précédent : 005D81; suivant : 005D83Anthelmintic efficacies of a tablet formula of ivermectin-praziquantel on horses experimentally infected with three Strongylus species
Auteurs : Stephane Bonneau [France] ; Laurence Maynard [France] ; Krzysztof Tomczuk [Pologne] ; Dawid Kok [Afrique du Sud] ; Hyone-Myong Eun [France]Source :
- Parasitology research : (1987) [ 0932-0113 ] ; 2009.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
In this blinded randomized and controlled study, the anthelmintic efficacy of a tablet formula of ivermectin-praziquantel was evaluated in horses experimentally infected with three species of Strongylus larvae. Eighteen previously dewormed horses were inoculated on study day 0 with third-stage larvae of Strongylus vulgaris, Strongylus equinus, and Strongylus edentatus. The horses were randomly allocated to three groups (n=6): test-drug (tablet formula), positive-control (reference gel), and negative-control (placebo tablet). On day 56, the horses were treated once with the respective drugs. On day 95, the horses were sacrificed, and necropsy examinations were performed to assess the status of the parasite burden (L4 and immature L5) and pathological lesions on selected organs and tissues. By the criteria of worm counts, the test-drug and positive-control showed, respectively, 100% and 97.3% anthelmintic efficacies on S. vulgaris, 100% and 81.4% on S. equinus, and equally 100% on S. edentatus. However, the efficacies on S. equinus and S. edentatus should be taken only as face values considering their respective low worm counts in the placebo group. The S. vulgaris-induced arterial lesions were also reduced in the test-drug and positive-control groups with efficacies of 73.9% and 62.9%, respectively. No adverse reactions were observed with either of the drugs. Our data demonstrate that the Equimax tablet formula was as safe and efficacious as the gel formula anthelmintic on large strongyles in horses.
Affiliations:
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type="city">Carros</settlement></placeName></affiliation></author><author><name sortKey="Maynard, Laurence" sort="Maynard, Laurence" uniqKey="Maynard L" first="Laurence" last="Maynard">Laurence Maynard</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>R&D Department, Virbac S.A., B.P. 27</s1><s2>06511 Carros</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Carros</settlement></placeName></affiliation></author><author><name sortKey="Tomczuk, Krzysztof" sort="Tomczuk, Krzysztof" uniqKey="Tomczuk K" first="Krzysztof" last="Tomczuk">Krzysztof Tomczuk</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of parasitology and invasive disease, Veterinary faculty, Agricultural University of Lublin</s1><s2>Lublin</s2><s3>POL</s3><sZ>3 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Carros</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Parasitology research : (1987)</title><title level="j" type="abbreviated">Parasitol. res. : (1987)</title><idno type="ISSN">0932-0113</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Parasitology research : (1987)</title><title level="j" type="abbreviated">Parasitol. res. : (1987)</title><idno type="ISSN">0932-0113</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anthelmintic</term><term>Horse</term><term>Ivermectin</term><term>Parasite</term><term>Praziquantel</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Anthelminthique</term><term>Ivermectine</term><term>Praziquantel</term><term>Cheval</term><term>Parasite</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this blinded randomized and controlled study, the anthelmintic efficacy of a tablet formula of ivermectin-praziquantel was evaluated in horses experimentally infected with three species of Strongylus larvae. Eighteen previously dewormed horses were inoculated on study day 0 with third-stage larvae of Strongylus vulgaris, Strongylus equinus, and Strongylus edentatus. The horses were randomly allocated to three groups (n=6): test-drug (tablet formula), positive-control (reference gel), and negative-control (placebo tablet). On day 56, the horses were treated once with the respective drugs. On day 95, the horses were sacrificed, and necropsy examinations were performed to assess the status of the parasite burden (L4 and immature L5) and pathological lesions on selected organs and tissues. By the criteria of worm counts, the test-drug and positive-control showed, respectively, 100% and 97.3% anthelmintic efficacies on S. vulgaris, 100% and 81.4% on S. equinus, and equally 100% on S. edentatus. However, the efficacies on S. equinus and S. edentatus should be taken only as face values considering their respective low worm counts in the placebo group. The S. vulgaris-induced arterial lesions were also reduced in the test-drug and positive-control groups with efficacies of 73.9% and 62.9%, respectively. No adverse reactions were observed with either of the drugs. Our data demonstrate that the Equimax tablet formula was as safe and efficacious as the gel formula anthelmintic on large strongyles in horses.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>France</li><li>Pologne</li></country><region><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Carros</li></settlement></list><tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Bonneau, Stephane" sort="Bonneau, Stephane" uniqKey="Bonneau S" first="Stephane" last="Bonneau">Stephane Bonneau</name></region><name sortKey="Eun, Hyone Myong" sort="Eun, Hyone Myong" uniqKey="Eun H" first="Hyone-Myong" last="Eun">Hyone-Myong Eun</name><name sortKey="Maynard, Laurence" sort="Maynard, Laurence" uniqKey="Maynard L" first="Laurence" last="Maynard">Laurence Maynard</name></country><country name="Pologne"><noRegion><name sortKey="Tomczuk, Krzysztof" sort="Tomczuk, Krzysztof" uniqKey="Tomczuk K" first="Krzysztof" last="Tomczuk">Krzysztof Tomczuk</name></noRegion></country><country name="Afrique du Sud"><noRegion><name sortKey="Kok, Dawid" sort="Kok, Dawid" uniqKey="Kok D" first="Dawid" last="Kok">Dawid Kok</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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